Bryan Johnson

An adaptogen with real RCT data for stress and cortisol reduction — not Grade A because trial sizes are small and long-term data is limited.

A Krebs-cycle metabolite marketed as an 'age reversal' pill — the viral 8-year biological-age claim comes from an uncontrolled cohort, not the placebo trial actually built to test it.

Cold water immersion has decent evidence for reducing post-exercise soreness and inflammation, but the hype often outpaces what the science actually supports.

Hydrolyzed collagen with growing RCT evidence for skin elasticity and joint comfort, though the effect sizes are modest and the mechanisms are still debated.

The most-studied sports supplement in history — strong evidence for strength and power, emerging evidence for cognitive benefits.

Sodium, potassium, and magnesium for hydration and performance — replacing what you lose in sweat during prolonged exercise is settled, uncontroversial science.

The simplest amino acid with surprisingly good RCT evidence for improving sleep quality and supporting collagen synthesis.

HEPA air purifiers are a well-established, evidence-backed tool for reducing airborne allergens and particulate matter indoors — direct relief of allergy and asthma symptoms is plausible but less consistently supported.

Animal data on NAD+ restoration is genuinely exciting, but human evidence that it slows aging remains thin — the most hyped longevity buy relative to what's proven.

Red light therapy (photobiomodulation) has growing RCT support for skin health and exercise recovery, though optimal protocols are still being defined.

A medicinal mushroom with centuries of traditional use and interesting mechanistic data, but limited rigorous human evidence for immune and sleep claims.

A conditionally essential amino acid with solid evidence for cardiovascular protection and emerging longevity interest, though human lifespan data is still absent.

An antioxidant essential for immune function, collagen synthesis, and iron absorption — the immune benefit is modest and most reliable for shortening colds under heavy physical stress.