Goal

Sleep & Stress

9 products graded for this goal, sorted by strength of evidence.

Magnesium

A

A foundational mineral most people under-consume — strong for correcting inadequacy, modest (not magical) for sleep.

Sleep & StressHeart & CardiovascularMuscle & Athletic Performance

Melatonin

A

The most well-studied sleep supplement with strong evidence for sleep onset and jet lag — but effective at much lower doses than commonly sold.

Sleep & Stress

Ashwagandha

B

An adaptogen with real RCT data for stress and cortisol reduction — not Grade A because trial sizes are small and long-term data is limited.

Sleep & StressEnergy & FatigueMuscle & Athletic Performance

Glycine

B

The simplest amino acid with surprisingly good RCT evidence for improving sleep quality and supporting collagen synthesis.

Sleep & StressJoint & Bone

Inositol

B

A sugar alcohol with good RCT evidence for reducing anxiety and panic symptoms at high doses, with additional data for PCOS — but requires gram-level dosing.

Sleep & StressBrain & Cognitive

L-Theanine

B

A calming amino acid from tea with solid RCT evidence for reducing stress and improving focused attention — without causing drowsiness.

Sleep & StressBrain & Cognitive

Phosphatidylserine

B

A phospholipid with moderate RCT evidence for cognitive function in older adults and cortisol modulation after exercise — effects in healthy young adults are less established.

Brain & CognitiveSleep & Stress

Apigenin

C

A flavonoid abundant in chamomile with preliminary evidence suggesting mild relaxation and neuroprotective properties, though human data remains thin.

Sleep & StressBrain & Cognitive

Reishi

C

A medicinal mushroom with centuries of traditional use and interesting mechanistic data, but limited rigorous human evidence for immune and sleep claims.

ImmuneSleep & Stress

When the evidence changes, we’ll tell you.

One short email a month. New A-grades, downgraded claims, and reader questions.

Medical disclaimer. The information on this site is provided for educational purposes only and is not intended as medical advice. It does not constitute a diagnosis, treatment plan, or recommendation for any specific health condition. Always consult a qualified healthcare professional before making changes to your supplement regimen, diet, or lifestyle — especially if you are pregnant, nursing, taking medications, or managing a medical condition.

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