Mark Hyman

A dual water/fat-soluble antioxidant with solid evidence for diabetic neuropathy and blood sugar support, and a reasonable safety profile.

An essential trace mineral required for energy production, connective tissue formation, and iron metabolism — rarely needed as a standalone supplement unless zinc supplementation depletes it.

A mitochondrial coenzyme critical for cellular energy production, with good evidence for heart health support and addressing statin-related depletion.

A medicinal mushroom with promising but preliminary evidence for improving oxygen utilization and endurance — most human trials are small and short.

The most-studied sports supplement in history — strong evidence for strength and power, emerging evidence for cognitive benefits.

Enzyme supplements with strong evidence for specific deficiencies like lactose intolerance, but much weaker evidence for general digestive discomfort in healthy people.

HEPA air purifiers are a well-established, evidence-backed tool for reducing airborne allergens and particulate matter indoors — direct relief of allergy and asthma symptoms is plausible but less consistently supported.

Infrared saunas show meaningful cardiovascular and recovery benefits, but detoxification and skin-health claims remain unproven by direct evidence.

An essential trace mineral required for thyroid hormone production — deficiency causes hypothyroidism and is common in regions without iodized salt, but excess can also disrupt thyroid function.

A calming amino acid from tea with solid RCT evidence for reducing stress and improving focused attention — without causing drowsiness.

An amino acid precursor to dopamine and norepinephrine with good evidence for preserving cognitive performance under acute stress — less clear benefit under normal conditions.

A medicinal mushroom with fascinating NGF-boosting potential in animal studies, but human clinical evidence remains limited to a few small pilot trials.

A foundational mineral most people under-consume — strong for correcting inadequacy, modest (not magical) for sleep.

The most well-studied sleep supplement with strong evidence for sleep onset and jet lag — but effective at much lower doses than commonly sold.

N-acetyl cysteine is a glutathione precursor with strong evidence for liver protection and respiratory support, backed by decades of clinical use.

Animal data on NAD+ restoration is genuinely exciting, but human evidence that it slows aging remains thin — the most hyped longevity buy relative to what's proven.

EPA and DHA from fish oil have strong cardiovascular and cognitive evidence — but dose, form, and freshness matter more than most labels suggest.

A phospholipid with moderate RCT evidence for cognitive function in older adults and cortisol modulation after exercise — effects in healthy young adults are less established.

Pyrroloquinoline quinone shows mitochondrial support in cell and animal studies, but human evidence is limited to small pilot trials with modest results.

Live microorganisms with real evidence for specific gut conditions — but strain specificity matters enormously, and most products don't tell you enough.

A medicinal mushroom with centuries of traditional use and interesting mechanistic data, but limited rigorous human evidence for immune and sleep claims.

An essential trace mineral critical for thyroid function and antioxidant defense — beneficial for those with low selenium status, but excess carries risk.

A Southeast Asian herb with emerging but limited human evidence for testosterone support, stress reduction, and physical performance.

An antioxidant essential for immune function, collagen synthesis, and iron absorption — the immune benefit is modest and most reliable for shortening colds under heavy physical stress.

The sunshine vitamin most indoor-dwellers are low in — strong evidence for bone health and immune function, reasonable for energy.

The most-studied protein supplement — strong and consistent evidence for supporting muscle protein synthesis, recovery, and lean mass gains when combined with resistance training.

An essential trace mineral with good evidence for immune support — most people get enough from food, but certain groups benefit from supplementation.