Heart & Cardiovascular

A foundational mineral most people under-consume — strong for correcting inadequacy, modest (not magical) for sleep.

EPA and DHA from fish oil have strong cardiovascular and cognitive evidence — but dose, form, and freshness matter more than most labels suggest.

Specifically the aged (Kyolic-style) form of garlic with several RCTs showing modest but real reductions in blood pressure and cholesterol.

A plant alkaloid with strong clinical evidence for lowering blood sugar, often compared to metformin in efficacy for glycemic control.

A methyl donor with solid evidence for lowering homocysteine and moderate evidence for improving power output and body composition during resistance training.

An amino acid that boosts nitric oxide production — good evidence for improving exercise performance and blood flow, though effect sizes are moderate and study quality varies.

A mitochondrial coenzyme critical for cellular energy production, with good evidence for heart health support and addressing statin-related depletion.

One of the most-studied herbal supplements in history, with mixed but meaningful evidence for circulation and cognition — though the large dementia-prevention trials were negative.

A conditionally essential amino acid with solid evidence for cardiovascular protection and emerging longevity interest, though human lifespan data is still absent.

A fat-soluble antioxidant that protects cell membranes — essential from food, but supplementation evidence is mixed and high doses may carry risk.

Directs calcium toward bones and teeth and away from arteries — promising evidence for cardiovascular and skeletal health, especially alongside vitamin D.

The famous 'red wine molecule' has disappointing human translational evidence despite decades of hype — a classic case of animal data not panning out.