Skin & Anti-Aging

An antioxidant essential for immune function, collagen synthesis, and iron absorption — the immune benefit is modest and most reliable for shortening colds under heavy physical stress.

Hydrolyzed collagen with growing RCT evidence for skin elasticity and joint comfort, though the effect sizes are modest and the mechanisms are still debated.

A newer entrant in oral form — RCT evidence backs skin hydration and mild knee osteoarthritis relief, but trials are small and often blend HA with other ingredients.

Infrared saunas show meaningful cardiovascular and recovery benefits, but detoxification and skin-health claims remain unproven by direct evidence.

The carotenoids behind the biggest eye-health trial ever run — the primary endpoint missed, but the safer beta-carotene swap and subgroup data hold up.

A flavonoid with decent anti-inflammatory and immune evidence, plus emerging senolytic interest when paired with dasatinib.

Red light therapy (photobiomodulation) has growing RCT support for skin health and exercise recovery, though optimal protocols are still being defined.

The most rigorously trialed mitophagy compound in longevity — real signals for muscle strength and immune aging, but every human trial to date has been funded by the company that sells it.

A fat-soluble antioxidant that protects cell membranes — essential from food, but supplementation evidence is mixed and high doses may carry risk.

A potent carotenoid antioxidant with real (if modest) human evidence for skin protection and exercise recovery — the 'longevity vitamin' framing is mouse data, not human.

The hair-skin-nails vitamin everyone buys — helps if you're actually deficient (rare), unproven if you're not, and high doses can scramble a heart-attack blood test.

A Krebs-cycle metabolite marketed as an 'age reversal' pill — the viral 8-year biological-age claim comes from an uncontrolled cohort, not the placebo trial actually built to test it.

A real adrenal hormone that declines sharply with age — genuine hormonal effects are well documented, but proven functional benefits in healthy adults are thin, and it's banned in competitive sport.

A senolytic flavonoid with striking mouse data on clearing senescent cells, but human clinical trials are only just beginning — the longevity case is still unproven.

Animal data on NAD+ restoration is genuinely exciting, but human evidence that it slows aging remains thin — the most hyped longevity buy relative to what's proven.

The famous 'red wine molecule' has disappointing human translational evidence despite decades of hype — a classic case of animal data not panning out.

An autophagy-promoting polyamine with promising epidemiological links to longevity, but interventional human evidence is still early-stage.

An essential fat-soluble vitamin for vision, immune function, and skin integrity — most people get enough from food, but deficiency remains a global health concern.